R/tte-sim.R
calc_study_duration.RdCalculate the analysis time based on a target number of events
calc_study_duration(
study_time,
observed_time,
event_indicator,
target_events = NULL,
target_follow_up = NULL
)Vector of study (accrual + observed) times
Vector of observed times
Vector of boolean values (True/False or 1/0) indicating if the observed time value is an event or censoring
Number of target events, if only using target follow-up time leave NULL
Target follow-up for each subject, if only using target events leave NULL
Time of analysis
library(dplyr)
# Determining analysis time by reaching a number of events
ex_tte_df |> mutate(
analysis_time = calc_study_duration(study_time = total_time, observed_time = y,
event_indicator = event, target_events = 30)
)
#> subjid y enr_time total_time event cov1 cov2 cov3 cov4
#> 1 1 4.94132575 0.914830838 5.856157 0 62 1 0 0
#> 2 2 13.48784696 0.818347654 34.120433 0 68 1 0 0
#> 3 3 4.08557603 1.234845352 5.320421 1 54 1 0 1
#> 4 4 12.54853421 1.757660399 18.259145 0 37 1 0 0
#> 5 5 11.60144136 1.519444841 13.120886 1 64 0 1 1
#> 6 6 13.06419095 1.242003662 17.094510 0 58 0 1 1
#> 7 7 9.81314580 1.058963733 10.872110 1 67 0 0 1
#> 8 8 8.32546909 1.739833746 10.065303 1 57 0 0 0
#> 9 9 12.22300778 0.005328632 12.228336 1 73 0 0 0
#> 10 10 2.18070722 1.209103289 3.389811 1 65 0 0 0
#> 11 11 1.87453932 0.938280275 2.812820 1 71 0 1 1
#> 12 12 13.03537379 1.270820822 28.926599 0 55 0 0 0
#> 13 13 13.58968582 0.120243722 13.709930 1 63 0 1 0
#> 14 14 3.85157607 0.879423183 4.730999 1 68 0 0 0
#> 15 15 1.23871879 0.028882144 1.267601 1 64 0 1 1
#> 16 16 8.02534813 0.225453192 8.250801 1 82 1 0 0
#> 17 17 4.14391880 0.848946745 4.992866 1 45 0 0 0
#> 18 18 11.65283579 1.893318857 13.546155 0 73 0 0 0
#> 19 19 4.60972545 1.143453675 5.753179 1 65 0 0 1
#> 20 20 6.97459156 0.552640099 7.527232 1 74 0 1 1
#> 21 21 12.78742955 1.518765057 16.883155 0 64 1 0 0
#> 22 22 3.40359707 1.135579805 4.539177 1 38 0 1 0
#> 23 23 10.70343388 1.801794218 12.505228 1 69 1 0 1
#> 24 24 2.57956045 1.801857366 4.381418 1 63 0 0 0
#> 25 25 8.97807945 1.667375555 10.645455 1 55 0 0 1
#> 26 26 1.07397237 0.979580768 2.053553 1 58 0 1 0
#> 27 27 13.45647204 0.849722569 39.847723 0 66 1 1 0
#> 28 28 10.56432229 0.530742681 11.095065 1 90 0 0 1
#> 29 29 13.60629872 0.699895892 14.749382 0 67 0 0 1
#> 30 30 9.66509057 1.287793164 10.952884 1 55 1 0 0
#> 31 31 12.99654787 1.309646739 21.987621 0 84 0 1 0
#> 32 32 0.64072655 0.803063575 1.443790 1 61 1 0 0
#> 33 33 12.41001105 1.896183561 38.443438 0 57 0 0 1
#> 34 34 1.52626737 1.675651089 3.201918 0 53 0 1 1
#> 35 35 5.86099717 0.856978191 6.717975 1 58 0 0 1
#> 36 36 12.54889557 1.757299039 35.511939 0 84 0 0 0
#> 37 37 6.62993839 0.182591691 6.812530 0 74 0 1 0
#> 38 38 9.63003796 0.658219346 10.288257 1 72 1 0 0
#> 39 39 10.85368481 0.882857819 11.736543 1 66 0 1 1
#> 40 40 8.72428218 1.356662716 10.080945 1 68 1 1 1
#> 41 41 12.49996325 1.806231361 33.485484 0 71 0 0 1
#> 42 42 1.80517492 0.790120253 2.595295 1 67 0 0 1
#> 43 43 1.11816335 0.322014023 1.440177 1 67 1 0 0
#> 44 44 9.64377430 1.638116490 11.281891 1 75 1 0 1
#> 45 45 3.69218383 1.943357178 5.635541 1 63 0 0 0
#> 46 46 10.17686106 1.896202200 12.073063 1 68 1 1 0
#> 47 47 12.78212492 1.524069688 16.497252 0 56 1 0 0
#> 48 48 13.32399282 0.982201790 23.498352 0 81 0 0 0
#> 49 49 2.35230418 0.775603405 3.127908 1 79 1 1 1
#> 50 50 11.79858863 1.343483454 13.142072 1 47 0 0 1
#> 51 51 13.10875140 1.197443212 14.972792 0 63 0 0 0
#> 52 52 13.74045847 0.565736139 35.274691 0 70 1 1 0
#> 53 53 9.08213968 1.864018058 10.946158 1 70 0 0 0
#> 54 54 9.89000393 0.615678150 10.505682 1 73 0 1 0
#> 55 55 13.74927445 0.556920157 16.984721 0 61 1 0 1
#> 56 56 11.57290297 0.207753573 11.780657 1 53 0 1 0
#> 57 57 0.82052430 0.859835137 1.680359 1 68 0 0 1
#> 58 58 13.78174289 0.524451723 14.406547 0 50 1 1 0
#> 59 59 6.14890044 1.806120872 7.955021 1 71 0 0 1
#> 60 60 6.51968350 1.235754918 7.755438 1 72 0 0 0
#> 61 61 12.46898554 1.837209076 18.695948 0 46 0 0 1
#> 62 62 13.05387397 1.252320643 15.624370 0 74 0 0 0
#> 63 63 8.08749313 1.101818035 9.189311 1 63 0 1 1
#> 64 64 7.78842293 1.889389239 9.677812 0 58 0 0 1
#> 65 65 2.25040964 1.499576018 3.749986 1 69 0 1 0
#> 66 66 12.69776464 1.608429969 17.494943 0 78 1 1 0
#> 67 67 9.16383335 1.168298671 10.332132 1 81 1 0 1
#> 68 68 3.36597674 1.300473365 4.666450 1 53 0 1 0
#> 69 69 4.92655148 1.896022630 6.822574 1 61 0 1 0
#> 70 70 8.50123185 1.560888817 10.062121 1 66 0 1 0
#> 71 71 2.09644996 1.193078713 3.289529 1 66 0 1 0
#> 72 72 3.67824483 1.937894981 5.616140 1 61 1 1 1
#> 73 73 14.00702626 0.299168351 20.371623 0 42 0 1 0
#> 74 74 12.81575901 1.490435606 20.256197 0 62 1 0 1
#> 75 75 13.57336144 0.732833170 14.483309 0 53 1 1 0
#> 76 76 11.10688793 1.886916388 12.993804 1 65 0 0 1
#> 77 77 13.65067103 0.655523577 18.081300 0 57 0 0 1
#> 78 78 12.71901840 1.587176209 15.183450 0 64 1 1 0
#> 79 79 4.15625220 1.393965260 5.550217 1 58 1 1 1
#> 80 80 13.28628838 1.019906234 23.154971 0 61 0 1 0
#> 81 81 12.96133651 1.344858098 36.578636 0 61 1 0 1
#> 82 82 12.74166548 1.564529136 16.565988 0 78 1 0 0
#> 83 83 13.71994020 0.586254409 15.912818 0 72 0 0 0
#> 84 84 9.35946924 0.375226433 9.734696 1 63 0 0 0
#> 85 85 3.01751638 1.844514892 4.862031 1 53 0 0 1
#> 86 86 13.01897227 1.287222342 23.352188 0 75 1 1 0
#> 87 87 8.62617477 1.341378423 9.967553 1 51 0 0 1
#> 88 88 12.86706587 1.439128740 21.357161 0 53 0 0 1
#> 89 89 12.87804488 1.428149728 16.888720 0 57 1 0 1
#> 90 90 11.01227336 1.535467605 12.547741 1 55 1 1 1
#> 91 91 6.08868565 1.881745142 7.970431 1 56 0 1 1
#> 92 92 13.04343279 1.262761817 18.356970 0 78 0 0 0
#> 93 93 6.12439409 1.053863459 7.178258 1 64 1 1 1
#> 94 94 12.96875082 1.337443796 14.688302 0 58 1 0 1
#> 95 95 7.74485260 1.011529981 8.756383 1 72 0 1 0
#> 96 96 3.78752871 1.476114000 5.263643 1 67 0 1 0
#> 97 97 9.29108586 0.510322453 9.801408 1 53 0 1 1
#> 98 98 13.52633582 0.779858791 22.261231 0 59 0 0 1
#> 99 99 10.82174912 1.258490415 12.080240 1 70 0 1 0
#> 100 100 12.37330713 1.932887477 64.793189 0 85 0 0 1
#> 101 101 12.54265890 1.763535714 21.988571 0 81 1 1 0
#> 102 102 0.32258255 1.975701769 2.298284 1 73 1 0 0
#> 103 103 12.27606151 1.458822752 13.734884 1 65 1 0 1
#> 104 104 7.43379836 1.242947810 8.676746 1 48 0 1 1
#> 105 105 4.10562201 1.628172625 5.733795 1 58 1 1 0
#> 106 106 13.02918631 1.277008304 16.655844 0 63 0 0 1
#> 107 107 1.20065513 0.082068380 1.282724 0 70 0 1 1
#> 108 108 12.44408288 1.862111733 16.601945 0 66 1 1 0
#> 109 109 0.87432668 0.316807468 1.191134 1 66 1 0 1
#> 110 110 12.73957392 1.566620693 33.263981 0 83 0 0 1
#> 111 111 4.22494864 1.517477012 5.742426 1 69 0 0 1
#> 112 112 12.59449656 1.711698053 19.436503 0 62 0 1 1
#> 113 113 13.15270437 1.153490246 19.173838 0 61 0 1 1
#> 114 114 3.95788320 1.799326662 5.757210 1 66 0 1 1
#> 115 115 6.00577017 1.786235661 7.792006 1 57 0 0 1
#> 116 116 12.42536031 1.880834302 14.607246 0 79 1 0 1
#> 117 117 8.14734538 1.692034146 9.839380 1 62 0 0 1
#> 118 118 9.64790719 1.520082211 11.167989 1 60 0 0 1
#> 119 119 2.01433411 1.060036130 3.074370 1 56 1 1 0
#> 120 120 12.57623427 0.082493735 12.658728 1 74 0 1 0
#> 121 121 12.49467829 1.811516325 31.410834 0 52 1 1 1
#> 122 122 12.96434451 1.341850099 19.787382 0 60 0 1 1
#> 123 123 5.45453170 1.417705139 6.872237 1 68 1 1 1
#> 124 124 2.50525420 0.267581866 2.772836 1 64 0 0 0
#> 125 125 10.79575829 1.966477632 12.762236 1 68 0 0 0
#> 126 126 2.31264350 1.852535335 4.165179 1 52 0 1 0
#> 127 127 9.48060040 1.570349637 11.050950 1 61 0 0 0
#> 128 128 11.13443937 1.395754128 12.530194 1 48 0 0 1
#> 129 129 3.47616704 0.605083683 4.081251 1 57 1 1 1
#> 130 130 8.13038758 1.690406155 9.820794 1 76 0 1 0
#> 131 131 12.33190613 1.974288478 15.909843 0 68 1 0 0
#> 132 132 8.22418119 1.931379354 10.155561 1 66 0 1 1
#> 133 133 4.85276585 1.548232521 6.400998 1 56 0 1 1
#> 134 134 0.05804212 1.330962458 1.389005 1 59 0 1 1
#> 135 135 12.94488076 1.361313854 17.709736 0 55 1 0 0
#> 136 136 6.02151730 1.299805567 7.321323 1 66 1 1 0
#> 137 137 4.40986751 1.853798855 6.263666 1 73 0 1 1
#> 138 138 8.66874462 0.035897000 8.704642 1 68 0 1 0
#> 139 139 2.00086094 1.877608366 3.878469 1 59 0 0 1
#> 140 140 2.90340600 1.965097878 4.868504 1 71 0 1 0
#> 141 141 1.85636615 0.106096841 1.962463 1 69 0 0 0
#> 142 142 12.79481388 1.511380730 14.306195 1 73 1 0 0
#> 143 143 8.56627347 0.890482330 9.456756 1 61 0 1 0
#> 144 144 6.60371347 0.910377387 7.514091 0 53 1 0 0
#> 145 145 13.28317358 1.023021036 29.058641 0 64 1 1 0
#> 146 146 12.75580602 1.550388596 17.047014 0 68 0 0 0
#> 147 147 11.97807985 0.681479206 12.659559 1 81 1 0 1
#> 148 148 7.94659194 0.721856450 8.668448 1 64 1 0 0
#> 149 149 7.24514393 1.648348195 8.893492 1 69 0 1 0
#> 150 150 5.52341669 1.307768784 6.831185 1 64 0 1 0
#> analysis_time
#> 1 5.550217
#> 2 5.550217
#> 3 5.550217
#> 4 5.550217
#> 5 5.550217
#> 6 5.550217
#> 7 5.550217
#> 8 5.550217
#> 9 5.550217
#> 10 5.550217
#> 11 5.550217
#> 12 5.550217
#> 13 5.550217
#> 14 5.550217
#> 15 5.550217
#> 16 5.550217
#> 17 5.550217
#> 18 5.550217
#> 19 5.550217
#> 20 5.550217
#> 21 5.550217
#> 22 5.550217
#> 23 5.550217
#> 24 5.550217
#> 25 5.550217
#> 26 5.550217
#> 27 5.550217
#> 28 5.550217
#> 29 5.550217
#> 30 5.550217
#> 31 5.550217
#> 32 5.550217
#> 33 5.550217
#> 34 5.550217
#> 35 5.550217
#> 36 5.550217
#> 37 5.550217
#> 38 5.550217
#> 39 5.550217
#> 40 5.550217
#> 41 5.550217
#> 42 5.550217
#> 43 5.550217
#> 44 5.550217
#> 45 5.550217
#> 46 5.550217
#> 47 5.550217
#> 48 5.550217
#> 49 5.550217
#> 50 5.550217
#> 51 5.550217
#> 52 5.550217
#> 53 5.550217
#> 54 5.550217
#> 55 5.550217
#> 56 5.550217
#> 57 5.550217
#> 58 5.550217
#> 59 5.550217
#> 60 5.550217
#> 61 5.550217
#> 62 5.550217
#> 63 5.550217
#> 64 5.550217
#> 65 5.550217
#> 66 5.550217
#> 67 5.550217
#> 68 5.550217
#> 69 5.550217
#> 70 5.550217
#> 71 5.550217
#> 72 5.550217
#> 73 5.550217
#> 74 5.550217
#> 75 5.550217
#> 76 5.550217
#> 77 5.550217
#> 78 5.550217
#> 79 5.550217
#> 80 5.550217
#> 81 5.550217
#> 82 5.550217
#> 83 5.550217
#> 84 5.550217
#> 85 5.550217
#> 86 5.550217
#> 87 5.550217
#> 88 5.550217
#> 89 5.550217
#> 90 5.550217
#> 91 5.550217
#> 92 5.550217
#> 93 5.550217
#> 94 5.550217
#> 95 5.550217
#> 96 5.550217
#> 97 5.550217
#> 98 5.550217
#> 99 5.550217
#> 100 5.550217
#> 101 5.550217
#> 102 5.550217
#> 103 5.550217
#> 104 5.550217
#> 105 5.550217
#> 106 5.550217
#> 107 5.550217
#> 108 5.550217
#> 109 5.550217
#> 110 5.550217
#> 111 5.550217
#> 112 5.550217
#> 113 5.550217
#> 114 5.550217
#> 115 5.550217
#> 116 5.550217
#> 117 5.550217
#> 118 5.550217
#> 119 5.550217
#> 120 5.550217
#> 121 5.550217
#> 122 5.550217
#> 123 5.550217
#> 124 5.550217
#> 125 5.550217
#> 126 5.550217
#> 127 5.550217
#> 128 5.550217
#> 129 5.550217
#> 130 5.550217
#> 131 5.550217
#> 132 5.550217
#> 133 5.550217
#> 134 5.550217
#> 135 5.550217
#> 136 5.550217
#> 137 5.550217
#> 138 5.550217
#> 139 5.550217
#> 140 5.550217
#> 141 5.550217
#> 142 5.550217
#> 143 5.550217
#> 144 5.550217
#> 145 5.550217
#> 146 5.550217
#> 147 5.550217
#> 148 5.550217
#> 149 5.550217
#> 150 5.550217
# Determining analysis time by minimum follow-up time
ex_tte_df |> mutate(
analysis_time = calc_study_duration(study_time = total_time, observed_time = y,
event_indicator = event, target_follow_up = 12)
)
#> subjid y enr_time total_time event cov1 cov2 cov3 cov4
#> 1 1 4.94132575 0.914830838 5.856157 0 62 1 0 0
#> 2 2 13.48784696 0.818347654 34.120433 0 68 1 0 0
#> 3 3 4.08557603 1.234845352 5.320421 1 54 1 0 1
#> 4 4 12.54853421 1.757660399 18.259145 0 37 1 0 0
#> 5 5 11.60144136 1.519444841 13.120886 1 64 0 1 1
#> 6 6 13.06419095 1.242003662 17.094510 0 58 0 1 1
#> 7 7 9.81314580 1.058963733 10.872110 1 67 0 0 1
#> 8 8 8.32546909 1.739833746 10.065303 1 57 0 0 0
#> 9 9 12.22300778 0.005328632 12.228336 1 73 0 0 0
#> 10 10 2.18070722 1.209103289 3.389811 1 65 0 0 0
#> 11 11 1.87453932 0.938280275 2.812820 1 71 0 1 1
#> 12 12 13.03537379 1.270820822 28.926599 0 55 0 0 0
#> 13 13 13.58968582 0.120243722 13.709930 1 63 0 1 0
#> 14 14 3.85157607 0.879423183 4.730999 1 68 0 0 0
#> 15 15 1.23871879 0.028882144 1.267601 1 64 0 1 1
#> 16 16 8.02534813 0.225453192 8.250801 1 82 1 0 0
#> 17 17 4.14391880 0.848946745 4.992866 1 45 0 0 0
#> 18 18 11.65283579 1.893318857 13.546155 0 73 0 0 0
#> 19 19 4.60972545 1.143453675 5.753179 1 65 0 0 1
#> 20 20 6.97459156 0.552640099 7.527232 1 74 0 1 1
#> 21 21 12.78742955 1.518765057 16.883155 0 64 1 0 0
#> 22 22 3.40359707 1.135579805 4.539177 1 38 0 1 0
#> 23 23 10.70343388 1.801794218 12.505228 1 69 1 0 1
#> 24 24 2.57956045 1.801857366 4.381418 1 63 0 0 0
#> 25 25 8.97807945 1.667375555 10.645455 1 55 0 0 1
#> 26 26 1.07397237 0.979580768 2.053553 1 58 0 1 0
#> 27 27 13.45647204 0.849722569 39.847723 0 66 1 1 0
#> 28 28 10.56432229 0.530742681 11.095065 1 90 0 0 1
#> 29 29 13.60629872 0.699895892 14.749382 0 67 0 0 1
#> 30 30 9.66509057 1.287793164 10.952884 1 55 1 0 0
#> 31 31 12.99654787 1.309646739 21.987621 0 84 0 1 0
#> 32 32 0.64072655 0.803063575 1.443790 1 61 1 0 0
#> 33 33 12.41001105 1.896183561 38.443438 0 57 0 0 1
#> 34 34 1.52626737 1.675651089 3.201918 0 53 0 1 1
#> 35 35 5.86099717 0.856978191 6.717975 1 58 0 0 1
#> 36 36 12.54889557 1.757299039 35.511939 0 84 0 0 0
#> 37 37 6.62993839 0.182591691 6.812530 0 74 0 1 0
#> 38 38 9.63003796 0.658219346 10.288257 1 72 1 0 0
#> 39 39 10.85368481 0.882857819 11.736543 1 66 0 1 1
#> 40 40 8.72428218 1.356662716 10.080945 1 68 1 1 1
#> 41 41 12.49996325 1.806231361 33.485484 0 71 0 0 1
#> 42 42 1.80517492 0.790120253 2.595295 1 67 0 0 1
#> 43 43 1.11816335 0.322014023 1.440177 1 67 1 0 0
#> 44 44 9.64377430 1.638116490 11.281891 1 75 1 0 1
#> 45 45 3.69218383 1.943357178 5.635541 1 63 0 0 0
#> 46 46 10.17686106 1.896202200 12.073063 1 68 1 1 0
#> 47 47 12.78212492 1.524069688 16.497252 0 56 1 0 0
#> 48 48 13.32399282 0.982201790 23.498352 0 81 0 0 0
#> 49 49 2.35230418 0.775603405 3.127908 1 79 1 1 1
#> 50 50 11.79858863 1.343483454 13.142072 1 47 0 0 1
#> 51 51 13.10875140 1.197443212 14.972792 0 63 0 0 0
#> 52 52 13.74045847 0.565736139 35.274691 0 70 1 1 0
#> 53 53 9.08213968 1.864018058 10.946158 1 70 0 0 0
#> 54 54 9.89000393 0.615678150 10.505682 1 73 0 1 0
#> 55 55 13.74927445 0.556920157 16.984721 0 61 1 0 1
#> 56 56 11.57290297 0.207753573 11.780657 1 53 0 1 0
#> 57 57 0.82052430 0.859835137 1.680359 1 68 0 0 1
#> 58 58 13.78174289 0.524451723 14.406547 0 50 1 1 0
#> 59 59 6.14890044 1.806120872 7.955021 1 71 0 0 1
#> 60 60 6.51968350 1.235754918 7.755438 1 72 0 0 0
#> 61 61 12.46898554 1.837209076 18.695948 0 46 0 0 1
#> 62 62 13.05387397 1.252320643 15.624370 0 74 0 0 0
#> 63 63 8.08749313 1.101818035 9.189311 1 63 0 1 1
#> 64 64 7.78842293 1.889389239 9.677812 0 58 0 0 1
#> 65 65 2.25040964 1.499576018 3.749986 1 69 0 1 0
#> 66 66 12.69776464 1.608429969 17.494943 0 78 1 1 0
#> 67 67 9.16383335 1.168298671 10.332132 1 81 1 0 1
#> 68 68 3.36597674 1.300473365 4.666450 1 53 0 1 0
#> 69 69 4.92655148 1.896022630 6.822574 1 61 0 1 0
#> 70 70 8.50123185 1.560888817 10.062121 1 66 0 1 0
#> 71 71 2.09644996 1.193078713 3.289529 1 66 0 1 0
#> 72 72 3.67824483 1.937894981 5.616140 1 61 1 1 1
#> 73 73 14.00702626 0.299168351 20.371623 0 42 0 1 0
#> 74 74 12.81575901 1.490435606 20.256197 0 62 1 0 1
#> 75 75 13.57336144 0.732833170 14.483309 0 53 1 1 0
#> 76 76 11.10688793 1.886916388 12.993804 1 65 0 0 1
#> 77 77 13.65067103 0.655523577 18.081300 0 57 0 0 1
#> 78 78 12.71901840 1.587176209 15.183450 0 64 1 1 0
#> 79 79 4.15625220 1.393965260 5.550217 1 58 1 1 1
#> 80 80 13.28628838 1.019906234 23.154971 0 61 0 1 0
#> 81 81 12.96133651 1.344858098 36.578636 0 61 1 0 1
#> 82 82 12.74166548 1.564529136 16.565988 0 78 1 0 0
#> 83 83 13.71994020 0.586254409 15.912818 0 72 0 0 0
#> 84 84 9.35946924 0.375226433 9.734696 1 63 0 0 0
#> 85 85 3.01751638 1.844514892 4.862031 1 53 0 0 1
#> 86 86 13.01897227 1.287222342 23.352188 0 75 1 1 0
#> 87 87 8.62617477 1.341378423 9.967553 1 51 0 0 1
#> 88 88 12.86706587 1.439128740 21.357161 0 53 0 0 1
#> 89 89 12.87804488 1.428149728 16.888720 0 57 1 0 1
#> 90 90 11.01227336 1.535467605 12.547741 1 55 1 1 1
#> 91 91 6.08868565 1.881745142 7.970431 1 56 0 1 1
#> 92 92 13.04343279 1.262761817 18.356970 0 78 0 0 0
#> 93 93 6.12439409 1.053863459 7.178258 1 64 1 1 1
#> 94 94 12.96875082 1.337443796 14.688302 0 58 1 0 1
#> 95 95 7.74485260 1.011529981 8.756383 1 72 0 1 0
#> 96 96 3.78752871 1.476114000 5.263643 1 67 0 1 0
#> 97 97 9.29108586 0.510322453 9.801408 1 53 0 1 1
#> 98 98 13.52633582 0.779858791 22.261231 0 59 0 0 1
#> 99 99 10.82174912 1.258490415 12.080240 1 70 0 1 0
#> 100 100 12.37330713 1.932887477 64.793189 0 85 0 0 1
#> 101 101 12.54265890 1.763535714 21.988571 0 81 1 1 0
#> 102 102 0.32258255 1.975701769 2.298284 1 73 1 0 0
#> 103 103 12.27606151 1.458822752 13.734884 1 65 1 0 1
#> 104 104 7.43379836 1.242947810 8.676746 1 48 0 1 1
#> 105 105 4.10562201 1.628172625 5.733795 1 58 1 1 0
#> 106 106 13.02918631 1.277008304 16.655844 0 63 0 0 1
#> 107 107 1.20065513 0.082068380 1.282724 0 70 0 1 1
#> 108 108 12.44408288 1.862111733 16.601945 0 66 1 1 0
#> 109 109 0.87432668 0.316807468 1.191134 1 66 1 0 1
#> 110 110 12.73957392 1.566620693 33.263981 0 83 0 0 1
#> 111 111 4.22494864 1.517477012 5.742426 1 69 0 0 1
#> 112 112 12.59449656 1.711698053 19.436503 0 62 0 1 1
#> 113 113 13.15270437 1.153490246 19.173838 0 61 0 1 1
#> 114 114 3.95788320 1.799326662 5.757210 1 66 0 1 1
#> 115 115 6.00577017 1.786235661 7.792006 1 57 0 0 1
#> 116 116 12.42536031 1.880834302 14.607246 0 79 1 0 1
#> 117 117 8.14734538 1.692034146 9.839380 1 62 0 0 1
#> 118 118 9.64790719 1.520082211 11.167989 1 60 0 0 1
#> 119 119 2.01433411 1.060036130 3.074370 1 56 1 1 0
#> 120 120 12.57623427 0.082493735 12.658728 1 74 0 1 0
#> 121 121 12.49467829 1.811516325 31.410834 0 52 1 1 1
#> 122 122 12.96434451 1.341850099 19.787382 0 60 0 1 1
#> 123 123 5.45453170 1.417705139 6.872237 1 68 1 1 1
#> 124 124 2.50525420 0.267581866 2.772836 1 64 0 0 0
#> 125 125 10.79575829 1.966477632 12.762236 1 68 0 0 0
#> 126 126 2.31264350 1.852535335 4.165179 1 52 0 1 0
#> 127 127 9.48060040 1.570349637 11.050950 1 61 0 0 0
#> 128 128 11.13443937 1.395754128 12.530194 1 48 0 0 1
#> 129 129 3.47616704 0.605083683 4.081251 1 57 1 1 1
#> 130 130 8.13038758 1.690406155 9.820794 1 76 0 1 0
#> 131 131 12.33190613 1.974288478 15.909843 0 68 1 0 0
#> 132 132 8.22418119 1.931379354 10.155561 1 66 0 1 1
#> 133 133 4.85276585 1.548232521 6.400998 1 56 0 1 1
#> 134 134 0.05804212 1.330962458 1.389005 1 59 0 1 1
#> 135 135 12.94488076 1.361313854 17.709736 0 55 1 0 0
#> 136 136 6.02151730 1.299805567 7.321323 1 66 1 1 0
#> 137 137 4.40986751 1.853798855 6.263666 1 73 0 1 1
#> 138 138 8.66874462 0.035897000 8.704642 1 68 0 1 0
#> 139 139 2.00086094 1.877608366 3.878469 1 59 0 0 1
#> 140 140 2.90340600 1.965097878 4.868504 1 71 0 1 0
#> 141 141 1.85636615 0.106096841 1.962463 1 69 0 0 0
#> 142 142 12.79481388 1.511380730 14.306195 1 73 1 0 0
#> 143 143 8.56627347 0.890482330 9.456756 1 61 0 1 0
#> 144 144 6.60371347 0.910377387 7.514091 0 53 1 0 0
#> 145 145 13.28317358 1.023021036 29.058641 0 64 1 1 0
#> 146 146 12.75580602 1.550388596 17.047014 0 68 0 0 0
#> 147 147 11.97807985 0.681479206 12.659559 1 81 1 0 1
#> 148 148 7.94659194 0.721856450 8.668448 1 64 1 0 0
#> 149 149 7.24514393 1.648348195 8.893492 1 69 0 1 0
#> 150 150 5.52341669 1.307768784 6.831185 1 64 0 1 0
#> analysis_time
#> 1 13.51138
#> 2 13.51138
#> 3 13.51138
#> 4 13.51138
#> 5 13.51138
#> 6 13.51138
#> 7 13.51138
#> 8 13.51138
#> 9 13.51138
#> 10 13.51138
#> 11 13.51138
#> 12 13.51138
#> 13 13.51138
#> 14 13.51138
#> 15 13.51138
#> 16 13.51138
#> 17 13.51138
#> 18 13.51138
#> 19 13.51138
#> 20 13.51138
#> 21 13.51138
#> 22 13.51138
#> 23 13.51138
#> 24 13.51138
#> 25 13.51138
#> 26 13.51138
#> 27 13.51138
#> 28 13.51138
#> 29 13.51138
#> 30 13.51138
#> 31 13.51138
#> 32 13.51138
#> 33 13.51138
#> 34 13.51138
#> 35 13.51138
#> 36 13.51138
#> 37 13.51138
#> 38 13.51138
#> 39 13.51138
#> 40 13.51138
#> 41 13.51138
#> 42 13.51138
#> 43 13.51138
#> 44 13.51138
#> 45 13.51138
#> 46 13.51138
#> 47 13.51138
#> 48 13.51138
#> 49 13.51138
#> 50 13.51138
#> 51 13.51138
#> 52 13.51138
#> 53 13.51138
#> 54 13.51138
#> 55 13.51138
#> 56 13.51138
#> 57 13.51138
#> 58 13.51138
#> 59 13.51138
#> 60 13.51138
#> 61 13.51138
#> 62 13.51138
#> 63 13.51138
#> 64 13.51138
#> 65 13.51138
#> 66 13.51138
#> 67 13.51138
#> 68 13.51138
#> 69 13.51138
#> 70 13.51138
#> 71 13.51138
#> 72 13.51138
#> 73 13.51138
#> 74 13.51138
#> 75 13.51138
#> 76 13.51138
#> 77 13.51138
#> 78 13.51138
#> 79 13.51138
#> 80 13.51138
#> 81 13.51138
#> 82 13.51138
#> 83 13.51138
#> 84 13.51138
#> 85 13.51138
#> 86 13.51138
#> 87 13.51138
#> 88 13.51138
#> 89 13.51138
#> 90 13.51138
#> 91 13.51138
#> 92 13.51138
#> 93 13.51138
#> 94 13.51138
#> 95 13.51138
#> 96 13.51138
#> 97 13.51138
#> 98 13.51138
#> 99 13.51138
#> 100 13.51138
#> 101 13.51138
#> 102 13.51138
#> 103 13.51138
#> 104 13.51138
#> 105 13.51138
#> 106 13.51138
#> 107 13.51138
#> 108 13.51138
#> 109 13.51138
#> 110 13.51138
#> 111 13.51138
#> 112 13.51138
#> 113 13.51138
#> 114 13.51138
#> 115 13.51138
#> 116 13.51138
#> 117 13.51138
#> 118 13.51138
#> 119 13.51138
#> 120 13.51138
#> 121 13.51138
#> 122 13.51138
#> 123 13.51138
#> 124 13.51138
#> 125 13.51138
#> 126 13.51138
#> 127 13.51138
#> 128 13.51138
#> 129 13.51138
#> 130 13.51138
#> 131 13.51138
#> 132 13.51138
#> 133 13.51138
#> 134 13.51138
#> 135 13.51138
#> 136 13.51138
#> 137 13.51138
#> 138 13.51138
#> 139 13.51138
#> 140 13.51138
#> 141 13.51138
#> 142 13.51138
#> 143 13.51138
#> 144 13.51138
#> 145 13.51138
#> 146 13.51138
#> 147 13.51138
#> 148 13.51138
#> 149 13.51138
#> 150 13.51138
# Or use both and whichever happens first
ex_tte_df |> mutate(
analysis_time = calc_study_duration(study_time = total_time, observed_time = y,
event_indicator = event,
target_events = 30, target_follow_up = 12)
)
#> subjid y enr_time total_time event cov1 cov2 cov3 cov4
#> 1 1 4.94132575 0.914830838 5.856157 0 62 1 0 0
#> 2 2 13.48784696 0.818347654 34.120433 0 68 1 0 0
#> 3 3 4.08557603 1.234845352 5.320421 1 54 1 0 1
#> 4 4 12.54853421 1.757660399 18.259145 0 37 1 0 0
#> 5 5 11.60144136 1.519444841 13.120886 1 64 0 1 1
#> 6 6 13.06419095 1.242003662 17.094510 0 58 0 1 1
#> 7 7 9.81314580 1.058963733 10.872110 1 67 0 0 1
#> 8 8 8.32546909 1.739833746 10.065303 1 57 0 0 0
#> 9 9 12.22300778 0.005328632 12.228336 1 73 0 0 0
#> 10 10 2.18070722 1.209103289 3.389811 1 65 0 0 0
#> 11 11 1.87453932 0.938280275 2.812820 1 71 0 1 1
#> 12 12 13.03537379 1.270820822 28.926599 0 55 0 0 0
#> 13 13 13.58968582 0.120243722 13.709930 1 63 0 1 0
#> 14 14 3.85157607 0.879423183 4.730999 1 68 0 0 0
#> 15 15 1.23871879 0.028882144 1.267601 1 64 0 1 1
#> 16 16 8.02534813 0.225453192 8.250801 1 82 1 0 0
#> 17 17 4.14391880 0.848946745 4.992866 1 45 0 0 0
#> 18 18 11.65283579 1.893318857 13.546155 0 73 0 0 0
#> 19 19 4.60972545 1.143453675 5.753179 1 65 0 0 1
#> 20 20 6.97459156 0.552640099 7.527232 1 74 0 1 1
#> 21 21 12.78742955 1.518765057 16.883155 0 64 1 0 0
#> 22 22 3.40359707 1.135579805 4.539177 1 38 0 1 0
#> 23 23 10.70343388 1.801794218 12.505228 1 69 1 0 1
#> 24 24 2.57956045 1.801857366 4.381418 1 63 0 0 0
#> 25 25 8.97807945 1.667375555 10.645455 1 55 0 0 1
#> 26 26 1.07397237 0.979580768 2.053553 1 58 0 1 0
#> 27 27 13.45647204 0.849722569 39.847723 0 66 1 1 0
#> 28 28 10.56432229 0.530742681 11.095065 1 90 0 0 1
#> 29 29 13.60629872 0.699895892 14.749382 0 67 0 0 1
#> 30 30 9.66509057 1.287793164 10.952884 1 55 1 0 0
#> 31 31 12.99654787 1.309646739 21.987621 0 84 0 1 0
#> 32 32 0.64072655 0.803063575 1.443790 1 61 1 0 0
#> 33 33 12.41001105 1.896183561 38.443438 0 57 0 0 1
#> 34 34 1.52626737 1.675651089 3.201918 0 53 0 1 1
#> 35 35 5.86099717 0.856978191 6.717975 1 58 0 0 1
#> 36 36 12.54889557 1.757299039 35.511939 0 84 0 0 0
#> 37 37 6.62993839 0.182591691 6.812530 0 74 0 1 0
#> 38 38 9.63003796 0.658219346 10.288257 1 72 1 0 0
#> 39 39 10.85368481 0.882857819 11.736543 1 66 0 1 1
#> 40 40 8.72428218 1.356662716 10.080945 1 68 1 1 1
#> 41 41 12.49996325 1.806231361 33.485484 0 71 0 0 1
#> 42 42 1.80517492 0.790120253 2.595295 1 67 0 0 1
#> 43 43 1.11816335 0.322014023 1.440177 1 67 1 0 0
#> 44 44 9.64377430 1.638116490 11.281891 1 75 1 0 1
#> 45 45 3.69218383 1.943357178 5.635541 1 63 0 0 0
#> 46 46 10.17686106 1.896202200 12.073063 1 68 1 1 0
#> 47 47 12.78212492 1.524069688 16.497252 0 56 1 0 0
#> 48 48 13.32399282 0.982201790 23.498352 0 81 0 0 0
#> 49 49 2.35230418 0.775603405 3.127908 1 79 1 1 1
#> 50 50 11.79858863 1.343483454 13.142072 1 47 0 0 1
#> 51 51 13.10875140 1.197443212 14.972792 0 63 0 0 0
#> 52 52 13.74045847 0.565736139 35.274691 0 70 1 1 0
#> 53 53 9.08213968 1.864018058 10.946158 1 70 0 0 0
#> 54 54 9.89000393 0.615678150 10.505682 1 73 0 1 0
#> 55 55 13.74927445 0.556920157 16.984721 0 61 1 0 1
#> 56 56 11.57290297 0.207753573 11.780657 1 53 0 1 0
#> 57 57 0.82052430 0.859835137 1.680359 1 68 0 0 1
#> 58 58 13.78174289 0.524451723 14.406547 0 50 1 1 0
#> 59 59 6.14890044 1.806120872 7.955021 1 71 0 0 1
#> 60 60 6.51968350 1.235754918 7.755438 1 72 0 0 0
#> 61 61 12.46898554 1.837209076 18.695948 0 46 0 0 1
#> 62 62 13.05387397 1.252320643 15.624370 0 74 0 0 0
#> 63 63 8.08749313 1.101818035 9.189311 1 63 0 1 1
#> 64 64 7.78842293 1.889389239 9.677812 0 58 0 0 1
#> 65 65 2.25040964 1.499576018 3.749986 1 69 0 1 0
#> 66 66 12.69776464 1.608429969 17.494943 0 78 1 1 0
#> 67 67 9.16383335 1.168298671 10.332132 1 81 1 0 1
#> 68 68 3.36597674 1.300473365 4.666450 1 53 0 1 0
#> 69 69 4.92655148 1.896022630 6.822574 1 61 0 1 0
#> 70 70 8.50123185 1.560888817 10.062121 1 66 0 1 0
#> 71 71 2.09644996 1.193078713 3.289529 1 66 0 1 0
#> 72 72 3.67824483 1.937894981 5.616140 1 61 1 1 1
#> 73 73 14.00702626 0.299168351 20.371623 0 42 0 1 0
#> 74 74 12.81575901 1.490435606 20.256197 0 62 1 0 1
#> 75 75 13.57336144 0.732833170 14.483309 0 53 1 1 0
#> 76 76 11.10688793 1.886916388 12.993804 1 65 0 0 1
#> 77 77 13.65067103 0.655523577 18.081300 0 57 0 0 1
#> 78 78 12.71901840 1.587176209 15.183450 0 64 1 1 0
#> 79 79 4.15625220 1.393965260 5.550217 1 58 1 1 1
#> 80 80 13.28628838 1.019906234 23.154971 0 61 0 1 0
#> 81 81 12.96133651 1.344858098 36.578636 0 61 1 0 1
#> 82 82 12.74166548 1.564529136 16.565988 0 78 1 0 0
#> 83 83 13.71994020 0.586254409 15.912818 0 72 0 0 0
#> 84 84 9.35946924 0.375226433 9.734696 1 63 0 0 0
#> 85 85 3.01751638 1.844514892 4.862031 1 53 0 0 1
#> 86 86 13.01897227 1.287222342 23.352188 0 75 1 1 0
#> 87 87 8.62617477 1.341378423 9.967553 1 51 0 0 1
#> 88 88 12.86706587 1.439128740 21.357161 0 53 0 0 1
#> 89 89 12.87804488 1.428149728 16.888720 0 57 1 0 1
#> 90 90 11.01227336 1.535467605 12.547741 1 55 1 1 1
#> 91 91 6.08868565 1.881745142 7.970431 1 56 0 1 1
#> 92 92 13.04343279 1.262761817 18.356970 0 78 0 0 0
#> 93 93 6.12439409 1.053863459 7.178258 1 64 1 1 1
#> 94 94 12.96875082 1.337443796 14.688302 0 58 1 0 1
#> 95 95 7.74485260 1.011529981 8.756383 1 72 0 1 0
#> 96 96 3.78752871 1.476114000 5.263643 1 67 0 1 0
#> 97 97 9.29108586 0.510322453 9.801408 1 53 0 1 1
#> 98 98 13.52633582 0.779858791 22.261231 0 59 0 0 1
#> 99 99 10.82174912 1.258490415 12.080240 1 70 0 1 0
#> 100 100 12.37330713 1.932887477 64.793189 0 85 0 0 1
#> 101 101 12.54265890 1.763535714 21.988571 0 81 1 1 0
#> 102 102 0.32258255 1.975701769 2.298284 1 73 1 0 0
#> 103 103 12.27606151 1.458822752 13.734884 1 65 1 0 1
#> 104 104 7.43379836 1.242947810 8.676746 1 48 0 1 1
#> 105 105 4.10562201 1.628172625 5.733795 1 58 1 1 0
#> 106 106 13.02918631 1.277008304 16.655844 0 63 0 0 1
#> 107 107 1.20065513 0.082068380 1.282724 0 70 0 1 1
#> 108 108 12.44408288 1.862111733 16.601945 0 66 1 1 0
#> 109 109 0.87432668 0.316807468 1.191134 1 66 1 0 1
#> 110 110 12.73957392 1.566620693 33.263981 0 83 0 0 1
#> 111 111 4.22494864 1.517477012 5.742426 1 69 0 0 1
#> 112 112 12.59449656 1.711698053 19.436503 0 62 0 1 1
#> 113 113 13.15270437 1.153490246 19.173838 0 61 0 1 1
#> 114 114 3.95788320 1.799326662 5.757210 1 66 0 1 1
#> 115 115 6.00577017 1.786235661 7.792006 1 57 0 0 1
#> 116 116 12.42536031 1.880834302 14.607246 0 79 1 0 1
#> 117 117 8.14734538 1.692034146 9.839380 1 62 0 0 1
#> 118 118 9.64790719 1.520082211 11.167989 1 60 0 0 1
#> 119 119 2.01433411 1.060036130 3.074370 1 56 1 1 0
#> 120 120 12.57623427 0.082493735 12.658728 1 74 0 1 0
#> 121 121 12.49467829 1.811516325 31.410834 0 52 1 1 1
#> 122 122 12.96434451 1.341850099 19.787382 0 60 0 1 1
#> 123 123 5.45453170 1.417705139 6.872237 1 68 1 1 1
#> 124 124 2.50525420 0.267581866 2.772836 1 64 0 0 0
#> 125 125 10.79575829 1.966477632 12.762236 1 68 0 0 0
#> 126 126 2.31264350 1.852535335 4.165179 1 52 0 1 0
#> 127 127 9.48060040 1.570349637 11.050950 1 61 0 0 0
#> 128 128 11.13443937 1.395754128 12.530194 1 48 0 0 1
#> 129 129 3.47616704 0.605083683 4.081251 1 57 1 1 1
#> 130 130 8.13038758 1.690406155 9.820794 1 76 0 1 0
#> 131 131 12.33190613 1.974288478 15.909843 0 68 1 0 0
#> 132 132 8.22418119 1.931379354 10.155561 1 66 0 1 1
#> 133 133 4.85276585 1.548232521 6.400998 1 56 0 1 1
#> 134 134 0.05804212 1.330962458 1.389005 1 59 0 1 1
#> 135 135 12.94488076 1.361313854 17.709736 0 55 1 0 0
#> 136 136 6.02151730 1.299805567 7.321323 1 66 1 1 0
#> 137 137 4.40986751 1.853798855 6.263666 1 73 0 1 1
#> 138 138 8.66874462 0.035897000 8.704642 1 68 0 1 0
#> 139 139 2.00086094 1.877608366 3.878469 1 59 0 0 1
#> 140 140 2.90340600 1.965097878 4.868504 1 71 0 1 0
#> 141 141 1.85636615 0.106096841 1.962463 1 69 0 0 0
#> 142 142 12.79481388 1.511380730 14.306195 1 73 1 0 0
#> 143 143 8.56627347 0.890482330 9.456756 1 61 0 1 0
#> 144 144 6.60371347 0.910377387 7.514091 0 53 1 0 0
#> 145 145 13.28317358 1.023021036 29.058641 0 64 1 1 0
#> 146 146 12.75580602 1.550388596 17.047014 0 68 0 0 0
#> 147 147 11.97807985 0.681479206 12.659559 1 81 1 0 1
#> 148 148 7.94659194 0.721856450 8.668448 1 64 1 0 0
#> 149 149 7.24514393 1.648348195 8.893492 1 69 0 1 0
#> 150 150 5.52341669 1.307768784 6.831185 1 64 0 1 0
#> analysis_time
#> 1 5.550217
#> 2 5.550217
#> 3 5.550217
#> 4 5.550217
#> 5 5.550217
#> 6 5.550217
#> 7 5.550217
#> 8 5.550217
#> 9 5.550217
#> 10 5.550217
#> 11 5.550217
#> 12 5.550217
#> 13 5.550217
#> 14 5.550217
#> 15 5.550217
#> 16 5.550217
#> 17 5.550217
#> 18 5.550217
#> 19 5.550217
#> 20 5.550217
#> 21 5.550217
#> 22 5.550217
#> 23 5.550217
#> 24 5.550217
#> 25 5.550217
#> 26 5.550217
#> 27 5.550217
#> 28 5.550217
#> 29 5.550217
#> 30 5.550217
#> 31 5.550217
#> 32 5.550217
#> 33 5.550217
#> 34 5.550217
#> 35 5.550217
#> 36 5.550217
#> 37 5.550217
#> 38 5.550217
#> 39 5.550217
#> 40 5.550217
#> 41 5.550217
#> 42 5.550217
#> 43 5.550217
#> 44 5.550217
#> 45 5.550217
#> 46 5.550217
#> 47 5.550217
#> 48 5.550217
#> 49 5.550217
#> 50 5.550217
#> 51 5.550217
#> 52 5.550217
#> 53 5.550217
#> 54 5.550217
#> 55 5.550217
#> 56 5.550217
#> 57 5.550217
#> 58 5.550217
#> 59 5.550217
#> 60 5.550217
#> 61 5.550217
#> 62 5.550217
#> 63 5.550217
#> 64 5.550217
#> 65 5.550217
#> 66 5.550217
#> 67 5.550217
#> 68 5.550217
#> 69 5.550217
#> 70 5.550217
#> 71 5.550217
#> 72 5.550217
#> 73 5.550217
#> 74 5.550217
#> 75 5.550217
#> 76 5.550217
#> 77 5.550217
#> 78 5.550217
#> 79 5.550217
#> 80 5.550217
#> 81 5.550217
#> 82 5.550217
#> 83 5.550217
#> 84 5.550217
#> 85 5.550217
#> 86 5.550217
#> 87 5.550217
#> 88 5.550217
#> 89 5.550217
#> 90 5.550217
#> 91 5.550217
#> 92 5.550217
#> 93 5.550217
#> 94 5.550217
#> 95 5.550217
#> 96 5.550217
#> 97 5.550217
#> 98 5.550217
#> 99 5.550217
#> 100 5.550217
#> 101 5.550217
#> 102 5.550217
#> 103 5.550217
#> 104 5.550217
#> 105 5.550217
#> 106 5.550217
#> 107 5.550217
#> 108 5.550217
#> 109 5.550217
#> 110 5.550217
#> 111 5.550217
#> 112 5.550217
#> 113 5.550217
#> 114 5.550217
#> 115 5.550217
#> 116 5.550217
#> 117 5.550217
#> 118 5.550217
#> 119 5.550217
#> 120 5.550217
#> 121 5.550217
#> 122 5.550217
#> 123 5.550217
#> 124 5.550217
#> 125 5.550217
#> 126 5.550217
#> 127 5.550217
#> 128 5.550217
#> 129 5.550217
#> 130 5.550217
#> 131 5.550217
#> 132 5.550217
#> 133 5.550217
#> 134 5.550217
#> 135 5.550217
#> 136 5.550217
#> 137 5.550217
#> 138 5.550217
#> 139 5.550217
#> 140 5.550217
#> 141 5.550217
#> 142 5.550217
#> 143 5.550217
#> 144 5.550217
#> 145 5.550217
#> 146 5.550217
#> 147 5.550217
#> 148 5.550217
#> 149 5.550217
#> 150 5.550217